THE REGULATION OF METABOLIC HEALTH AND LONGEVITY BY SPECIFIC DIETARY MACRONUTRIENTS
Calorie restriction (CR), or reducing calorie intake without malnutrition, robustly extends lifespan in model organisms ranging from yeast to mammals. CR restricts the intake of all macronutrients (protein, carbohydrate, and fat), but whether the effects of a CR diet are mediated solely by reduced caloric intake or reduced consumption of specific macronutrients has long been unclear.
Over the last decade, research in organisms including flies and mice has highlighted a critical role for dietary protein in mediating longevity, with reduced consumption of dietary protein promoting longevity and improving metabolic health. However, the specific dietary components altered in a low protein diet that promote health and longevity remain unknown. In this talk, I will discuss ongoing research in my laboratory into the role of the three branched-chain amino acids (BCAAs; leucine, isoleucine, valine) in regulating metabolic health and longevity.
Time: 29 November 2018, 12:30.
Place: Auditorium 1, August Krogh Building, Universitetsparken 13, DK-2100 Copenhagen
Speaker: Assistant Professor Dudley Lamming, University of Wisconsin-Madison, US.