New insight into the storage and oxidation of circulating triglyceride in muscle and adipose tissue
Two new articles by Danish Diabetes Academy Post Doc Esben Søndergaard, in respectively Journal of Clincal Endocrinology & Metabolism and Scandinavian Journal of Medicine & Science in Sports (February 2017), provide new insight into the storage and oxidation of circulating triglyceride in muscle and adipose tissue in persons with and without type 2 diabetes.
MEN WITH TYPE 2 DIABETES HAVE INCREASED STORAGE OF TRIGLYCERIDE IN MUSCLES
Persons with type 2 diabetes have increased levels of circulating triglyceride. These higher levels of circulating lipid leads to an increased deposition in muscles. Since an increased lipid content in muscles are associated to insulin resistance, this may contribute to the development of type 2 diabetes.
LIPOPROTEIN LIPASE DOES NOT APPEAR TO REGULATE STORAGE IN MUSCLE AND ADIPOSE TISSUE
Lipoprotein lipase hydrolyze triglyceride to release fatty acids for uptake in muscle and fat. This has been perceived as the rate-limiting step. In these two studies, the association between the activity of lipoprotein lipase and transport of fatty acids from triglyceride has been investigated. This was studied both during rest and during exercise where the need for lipid for oxidation in muscles are increased. No association was observed between the activity of the enzyme and transport of lipid into muscles and fat arguing against lipoprotein lipase as the limiting step.
AUTHORS AND AFFILIATION
Increased VLDL-TG fatty acid storage in skeletal muscle in men with type 2 diabetes, Journal of Clincal Endocrinology & Metabolism
*Iben R. Andersen1, *Esben Søndergaard1,3,4, Lars P. Sørensen1, Birgitte Nellemann1, Lars C. Gormsen2, Michael D. Jensen3, and Søren Nielsen1
1Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
2Department of Nuclear Medicine and PET center, Aarhus University Hospital, Aarhus, Denmark
3Endocrine Research Unit, Mayo Clinic, Rochester, MN, USA
4 Danish Diabetes Academy, Odense, Denmark
*Iben R. Andersen and Esben Søndergaard are shared first authors
Lipoprotein Lipase Activity does not Predict VLDL-TG Fatty Acid Oxidation during Exercise, Scandinavian Journal of Medicine & Science in Sports
Esben Søndergaard1, 2, Iben R. Andersen1, Lars P. Sørensen1, Lars C. Gormsen3 and Søren Nielsen1
1Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Denmark
2 The Danish Diabetes Academy
3Department of Nuclear Medicine and PET center, Aarhus University Hospital, Aarhus, Denmark