Grant recipients
In accordance with the grant from the Novo Nordisk Foundation, the Danish Diabetes Academy is allocating co-financed PhD scholarships of each 550.000 DKK, Post Doc fellowships of each 600.000 DKK per year, and a number of Visiting Scientist grants.
The list below features the Danish Diabetes Academy funded PhD and Post Doc fellows, who have received a grant in 2015-2016 and a complete list of Visiting Scientist 2013-2016. Additionally, recipients of exchange travel grants 2016 are featured.
Skeletal muscle mitochondrial function is impaired in conditions of aging and type 2 diabetes mellitus (T2DM) suggesting that diminished skeletal muscle mitochondrial oxidative capacity is linked to the pathogenesis of aging- and lifestyle-related diseases. Therefore, understanding the regulatory mechanisms responsible for the aging- and T2DM-related decline in mitochondrial oxidative capacity in skeletal muscle is crucial in developing therapeutic and lifestyle-related strategies to maintain skeletal muscle metabolic function in these conditions.
The prevalence of Type 2 diabetes mellitus (T2DM) is increasing in Denmark as well as worldwide. The obesity epidemic is one of the main drivers behind this development. Since conventional obesity treatments are seldom long-term successful, focus has turned to surgical treatments of obesity and T2DM. One of the most common bariatric procedures, Roux-en-Y gastric bypass surgery (RYGB), does not only result in large, sustained weight loss, but also appears to substantially improve obesity-related co-morbidities including T2DM.
Diabetic nephropathy is a common complication that affects 10-30 % of diabetic patients and is characterized by albuminuria, hypertension and kidney tissue changes. Hypertension is known as a leading risk factor for heart disease, death and disability worldwide making it a great health burden. One of the strongest predictors of a poor outcome in diabetes and cardiovascular disease is the degree of renal damage as measured by aberrant loss of plasma albumin into urine.
The overall aim of this PhD project is to explore the influence of the oral microbiota on cardio metabolic traits in 702 well phenotyped individuals at different risk of type 2 diabetes mellitus from the ADDITION-Pro cohort. In a closer look, we have four different goals for this project:
For the past decades the prognosis for children with acute lymphoblastic leukaemia (ALL) has improved significantly with more than 85% being cured. This in part reflects intensive chemotherapy (amongst others, asparaginase) combined with high doses of steroids. However, the burden of therapy has increased proportionally.
A mechanistic understanding of organ regeneration is fundamental for developing tissue replacement therapies with which to treat injury or disease. With the overarching goal of understanding the regenerative capacity and cellular plasticity of the developing pancreas, I aim to explore the extent of tissue recovery, revealing the origin of the regenerating pancreatic cells and analyzing the signaling pathways involved in this process.
Insulin resistance is a central feature of T2DM and is the primary target for therapy. Nevertheless, the pathological consequences of T2DM predominantly relate to cerebro- and cardiovascular disease (CVD), representing the leading cause of morbidity and mortality in T2DM. Up to 60% of all deaths in T2DM are directly related to CVD, whilst patients with T2DM develop microvascular complications (e.g. retinopathy, nephropathy and neuropathy).